Isibhedlela sase-Heidelberg University

Buyekeza:Ukwelashwa kweBongo aneurysm inqubo yokuhlinzwa eyenziwa lapho ubungozi bokuqothuka kwe-aneurysm buye buphakeme impela. Isilinganiso sobude bokuhlala phesheya: amavikiIsikhathi esichithwe emtholampilo kuya ngohlobo lwe-aneurysm. Ngama-aneurysm angenayo i-plug, isikhathi sokululama ngemuva kokwelashwa sivame ukufushane kunokuba kuqhume ukukhipha.

I-acute lymphoblastic leukemia, ebuye ifushaniswe ngokuthi YONKE (ngezinhlamvu zokuqala zesifo), futhi kwesinye isikhathi ungathola igama le-acute lymphocytic leukemia - isifo esibuhlungu sohlelo lwe-hematopoietic. Lesi sifo siqala kumnkantsha wethambo. Umongo wethu wethambo uyimboni yamaseli egazi ahlukahlukene. Lapho umugqa wethambo ugula, khona-ke le fektri, esikhundleni seyenempilo (odokotela bakhuluma ngamangqamuzana avuthiwe), iqala ukukhiqiza inani elikhulu lamaseli egazi amhlophe angakafiki.Lapho umuntu egula, khona-ke wonke amaseli egazi akhula futhi avuselelwa ngokuvumelanayo, konke kwenzeka ngendlela elinganiselayo. Amaseli wegazi avuthwa kancane kancane, futhi inqubo yokuvuthwa iyinkimbinkimbi impela. Kepha niniingane iyagula ine-lymphoblastic leukemia, i.e.BONKE, inqubo yokuvuthwa iphula ngokuphelele.Amangqamuzana amhlophe egazi, okungukuthi, amangqamuzana amhlophe egazi, avele avele angavuthi ngokuphelele futhi angakhuli abe amaseli okusebenza agcwele. Esikhundleni salokho, baqala ukuhlanganyela ngokushesha nangokungalawuleki. Umsebenzi wohlelo lwe-hematopoietic uyaqhubeka nokusebenza ngokungafanele: amangqamuzana agulayo afaka amanye aphilile futhi abambelele endaweni yomongo. Ingane egulayo ayinawo amangqamuzana egazi amhlophe anempilo, amangqamuzana abomvu egazi (amaseli abomvu egazi), noma amaplatelet egazi (amaplatelet).Kungaleso sizathu izingane zingakha i-anemia (anemia), izinkinga ezithathelwanayo ezahlukahlukene (ukutheleleka), kanye nokuphuma kwegazi kaningi. Futhi lokhulezo yizimpawu zokuqala ezingakhuluma nge-leukemia ebukhali enganeni. Kepha lesi sifo uqobo, SONKE, kusukela ekuqaleni asitholakali kunoma iyiphi ingxenye yomzimba. Ukusuka emqubeni wethambo, ungena ungene egazini, ungene ezicutshini ze-lymphoid (uhlelo lwe-lymphatic) nakuzo zonke ezinye izitho zomzimba. Umsebenzi wohlelo lonke lwezitho, okungukuthi, umzimba wonke, uqala ukuphazamiseka. Kungakho ZONKE, njengazo zonke ezinye izinhlobo ze-leukemia, zibizwa ngokuthi isifo esibuhlungu esise-systemic, okungukuthi, lesi sifo sibulala wonke umzimba njengohlelo.KONKE kusakazeka emzimbeni wonke ngokushesha okukhulu. Ngaphandle kokwelashwa, amaseli we-leukemia aphambukeka yonke indawo, hhayiizithiyo zomhlangano. Izitho zomzimba lapho ziyeke khona ukusebenza ngokujwayelekile kanti nezifo ezintsha ezinkulu ziqala kuzo. Uma i-leukemia ingelashwa, khona-ke ukufa kwenzeka ezinyangeni ezimbalwa.Shiya isicelo samahhala kwiwebhusayithi yethu futhi ochwepheshe bethu bazokuthinta bakusize ukhethe umtholampilo ohamba phambili ngokulandela icala lakho. Indlela yokwelashwa yokwelapha i-leukemia ebukhali incike eminyakeni yobudala kanye nesiguli, uhlobo nesigaba sokuthuthuka kwalesi sifo, futhi kubalwa ngaso sonke isikhathi ngokwahlukana ngakunye esimweni ngasinye.Kunezinhlobo ezimbili eziyinhloko zokwelashwa kwe-leukemia ebukhali - ukwelashwa ngamakhemikhali nokwelashwa kokuhlinzwa - ukufakelwa kwamathambo.I-Chemotherapy yakhiwaizinyathelo ezimbili ezilandelanayo:• Inhloso yesigaba sokuqala ukutholwa kokuxolelwa. Ngama-chemotherapy, ama-oncologists athola ukwehla kwezinga lamaseli wokuqhuma• Isinyathelo sokuhlanganisa esidingekayo ukubhubhisa amaseli womdlavuza asele• Ukungenisa kabusha, njengomthetho, ukuphinda ngokuphelele uhlelo (izidakamizwa, imithamo, imvamisa yokuphatha) yesigaba sokuqala• Ngaphezu kwezidakamizwa ze-chemotherapeutic, ama-cytostatics akhona ohlelweni olujwayelekile lokwelashwa.Ngokwezibalo, ubude besikhathi sokwelashwa kwamakhemikhali kwe-leukemia acute cishe iminyaka emi-2.I-Chemotherapy ehlanganiswe ne-cytostatics iyiindlela enolaka yokuvezwa, okudala imiphumela emibi eminingana (isicanucanu, ukuhlanza, impilo engeyinhle, ukulahlekelwa izinwele, njll.). Ukuze kuncishiswe isimo sesiguli, kunqunywa ukwelashwa okufana. Ngaphezu kwalokho, kuya ngesimo, ama-antibiotics, ama-detoxification agents, ama-platelet ne-erythrocyte mass, nokunconywa kwegazi kunganconywa.Ukufakelwa kwamathamboUkufakelwa kwamathambo kunikeza isiguli amaseli anempilo we-stem, athi kamuva abe ngokhokho bamaseli egazi ajwayelekile.Isimo esibaluleke kakhulu sokudluliswa kwezidalwa kuyinto yokuxolelwa ngokuphelele kwesifo. Kubalulekile ukuthi umongo wethambo ohlanziwe kusuka kumaseli aqhuma ugcwaliswe ngamaseli anempilo.Ukuze ulungiselele isiguli ukuhlinzwa,Ukwelashwa okukhethekile kwe-immunosuppressive kuyenziwa. Lokhu kuyadingeka ukubhubhisa amaseli we-leukemia futhi kucindezele ukuzivikela komzimba ukuze kunciphise ingozi yokwenqatshwa.Ukuxhumana kokuthathwa kokufakelwa kwamathambo:• Ukwephulwa kokusebenza kwezitho zangaphakathi• Izifo ezithathelanayo ezingapheli• Ukubuyela emuva kwe-leukemia ebusayo, hhayi ukuhumushela ekuxolelweni• ukugugaShiya isicelo kuwebhusayithi yethu futhi ongoti bethu bazokuthinta bakusize ukhethe umtholampilo ohamba phambili ngokuhambisana necala lakho mahhala.

Into yokuqala iziguli nawo wonke umuntu wesifazane okudingeka ayazi ngomdlavuza webele (njengoba, ngempela, noma uluphi uhlobo lomdlavuza): namuhla lesi akusona isigwebo, isigaba sangaphambi kwesifo, amathuba aphezulu wokuhlula umdlavuza ngokuphelele. Futhi ezigabeni zakamuva, kunamathuba amaningi futhi amaningi okulwa ngempumelelo nesifo sibonga ukuqala kwezindlela zanamuhla zokuguqula izindlela zokwelapha (bheka ngezansi).Ubani osengozini? Umdlavuza webele yi-neoplasm ebabayo eyenzeka cishe koyedwa kwabesifazane abayishumi. Umdlavuza webele ungatholakala kunoma yimuphi ubudala, kepha ngemuva kweminyaka engama-65 yobudala, ubungoziUkwakheka kwesimila kukhuphuke amahlandla ayi-6 kunangaphambilini. Abaphenyi bakhomba izimbangela ezilandelayo zokukhula kwalesi sifo:1) ifa elisindayo: uma izihlobo, ikakhulukazi ohlangothini lukamama, zitholakale zinomdlavuza webele, izitho zangasese zowesifazane, nezinye izifo ze-oncological, khona-ke ingozi yokuthola umdlavuza webele iyanda;2) ukuqala kokuqala kokuya esikhathini (kuze kube yiminyaka eyi-12) kanye nokuqala kwesikhathi kokuya esikhathini (ngemuva kweminyaka engama-55);I-3) ukungazali inzalo, ukuzalwa kokufika sekwedlule isikhathi (ngemuva kweminyaka engama-30), ukuntuleka kokuqunjelwa yisisu noma isikhathi esifushane sokuncelisa ibele, i-postitis ye-mastitis;4) impilo yobulili engajwayelekile;5) ukulimala kwe-gland ye-mammary;6) ukuxilongwa kwe "dishormonalmammary gland hyperplasia ”;7) ukukhuluphala;8) ukungasebenzi kwegilo;9) ukwelashwa esikhundleni se-hormone.Izimpawu zomdlavuza webele Kwezokwelapha, isimila esiswini sezilwane ezincelisayo ezimweni eziningi sitholwa ngowesifazane noma oshade naye, okwenzeka futhi. Isimila singatholakala lapho kuhlolwa udokotela wezifo ezincelisayo, udokotela wezifo zamehlo, udokotela ohlinzayo, noma ukutholakala ngengozi ngesikhathi sokuhlolwa kwesibalo.Yiziphi izimpawu okufanele ziqwashise:    ngaphezu kokuzizwa ngemfundo ebeleni, owesifazane angabona izinguquko ezingalweni: ulceration, retraction, ubona kusukela ingono. Lesi yisikhathi sokubonana nodokotela ngokushesha!     ezigabeni zakamuva umakiubuthakathaka obukhulayo, ukuwohloka kwempilo, ukukhwehlela, ukuphefumula kanzima, ubuhlungu bethambo kungenzeka.Ukwelashwa Komdlavuza Webele Ukwelashwa umdlavuza webele kwenziwa ngezigaba eziningana kusetshenziswa izindlela ezahlukahlukene. Izindlela ezintathu eziphambili zisetshenziswa namuhla:Umuthi wokwelapha antitumor.Kunezinhlobo eziningi zokwelapha okunjalo, okungukuthi:* i-chemotherapy: kulokhu, izidakamizwa ezihlose ekubhujisweni kwamaseli e-tumor ziyasetshenziswa;* Ukwelashwa kwama-hormone, okungukuthi, ukusetshenziswa kwezidakamizwa ezicindezela ukusebenza kwe-hormonal kwesimila kanye nomzimba;* Ukwelapha okuqondisiwe kuyinkomba entsha, indlela lapho izidakamizwa “zibukhali” ngomphumela oqondiwe kumaseli we-tumor futhi kakhulu kuthinta abaphilileizicubu zomuntu;* I-Immunotherapy iyinkomba entsha kakhulu, namuhla ezinhlanganweni zamazwe omhlaba ze-oncologists ibizwa ngokuthi enye yezindlela eziphambili kakhulu nezikhuthazayo zokulwa nezinhlobo ezahlukene zomdlavuza. Umongo we-immunotherapy usezinhlelweni ezikhethekile zamaseli omzimba eziguli. Ngenxa yobuchwepheshe babo obuhlukile, baphenduka isikhali esinamandla esingabona futhi sibhubhise ngokunembile amaseli womdlavuza.Ngokuxilongwa komdlavuza webele, ukwelashwa okuhlinzwa nokwelashwa ngemisebe nakho kuyasetshenziswa.Shiya isicelo kuwebhusayithi yethu futhi ongoti bethu bazokuthinta bakusize ukhethe umtholampilo ohamba phambili ngokuhambisana necala lakho mahhala.

Yini okudingeka uyazi mayelana nenqubo yokutshelwa kokufakelwa Uma unquma ukwenza i-IVF?Emibhangqwaneni eminingi, i-IVF ukuphela kwendlela yokuba nengane elindelwe isikhathi eside. Uhlobo luni lwenqubo lolu, luphephile, kuhamba kanjani ukulungiselela i-IVF futhi kuzobiza malini?Umnyombo wenqubo ye-IVFIVF inqubo yokufaka umquba ngaphandle komzimba: amaqanda nesidoda asuswe emzimbeni, ukuvundiswa kwenzeka elabhoratri. Ngemuva kwalokho amaqanda avundisiwe afakwa ku-incubator izinsuku ezingama-5-6 futhi lapho kuhlukaniswa khona atshalwe esibelethweni.Izinkomba zeukuqokwaIVF kuboniswa ezimweni eziningi zokungazali: •ngaphezulu, kuvame ukuhambisana nobuchwepheshe bokulekelela.I-ICSI - ukwethulwa kwesidoda okwenziwa ngeqanda kusetshenziswa inaliti elincanyana kakhulu. Kwenziwe uma •izimo zaselebhu. Kuyasetshenziswa uma ukukhuthaza kwehluleka. Kugwema ukukhuthaza kwe-hormonal.Ukusikeka okusizayo kuwubuchwepheshe obunikeza amandla ukufakwa kombungu esibelethweni. Umbungu uzungezwe yigobolondo elincanyana, elichithwa ngaphambi kokufakwa.Ukulungiselela i-IVF, ukwenza inqubo nokubheka emva kwe-IVFUkulungiselela i-IVF kuthatha cishe amasonto ama-2-3 futhi kufaka nokuhlolwa kwabo bobabili abashadayo. Uhlelo lwe-IVF luvame ukufaka: •nullUma i-IVF inganikeli ngomphumela oyifunayo, eminye imibhangqwana iphendukela ezinsizakalweni zoomama ababa ngama-surrogate.Kwamanye amazwe, umthetho we-surrogacy wenqatshelwe ngumthetho, kepha kunamazwe lapho i-surrogacy idingeka khona kakhulu, ngokwesibonelo, eKazakhstan.Namuhla eRussia, Kazakhstan nakwamanye amazwe e-CIS, kungenzeka ukwenza i-IVF mahhala cishe nganoma yiluphi uhlobo lokuzala.Shiya isicelo kuwebhusayithi yethu futhi ongoti bethu bazokuthinta bakusize ukhethe umtholampilo ohamba phambili ngokuhambisana necala lakho mahhala.